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MiotolanComplete info about Miotolan
Furazabol was originally manufactured in Japan in tabs of 1 mg strength. Dan Duchaine was very unimpressed with this drug, noting that he rarely saw any very large Japanese bodybuilders. It has become quite popular ever since its reappearance on many underground labs' price lists. Finding out information on this stuff was agonizing, since most of it is in Japanese, and no athletes really use it. Anyway, with respect to its half-life and active life (and detection time). One study said that the half-lives of unchanged Furazabol in two human subjects were 1.87 and 1.29 h respectively, and the recovered amount in 48 h was averaged to 24% (33% for one, 15% for the other, respectively) (4). Unfortunately for tested athletes, Furazabol is metabolized in the body into 16-hydroxyfurazabol and then excreted in urine. The presence of this compound in urine can be monitored with a very simple, standard procedure (4) for urine screening, and this is incorporated into the general dope testing protocol for anabolic steroids employed by the IOC and other such no-fun-agencies. The really interesting thing about this stuff (to me, anyway) is that it's a DHTderived steroid, with a decent anabolic rating that lowers cholesterol! It is often compared with Winstrol, for many good reasons: structurally, it is a DHT molecule with a 17-alpha-methyl group (making it both liver-toxic and orally available, as you know). Additionally, it has no 3-keto group, which is needed for a strong androgenic binding ability, so this lack probably impairs its overall androgenic rating. As with Winstrol, it's not estrogenic in any way, doesn't aromatize, and you'll only have to worry about DHT-sides from it (acne, hairloss, etc.), and possible liver problems. However, while Winny really KILLS your cholesterol values, furazabol actually improves them! In one study, the administration of furazabol at the daily dose of 0.04, 0.2 or 1 mg/subject (in this case, rats) for 3 months, there were substantial increases noted in the plasminogen (a substance found in body fluids and blood plasma that, when activated, becomes plasmin—an enzyme found in plasma that catalyzes the breakdown of blood-clotting agents) activator activity in blood. Furthermore, in the rats' lung tissue there was an expected decrease in plasma fibrinogen level. This will, of course, serve to increase your blood-clotting time considerably. There was also a decrease in plasma cholesterol levels with administration of Furazabol (8), which certainly means it's a reasonably safe oral. One month after cessation of the furazabol treatment, these altered parameters tended to return to normal (8), as is very common with similar side effects from most anabolic steroids (notably, this is very similar to Winny, once again). This steroid is quite confusing to me, as it was found to be a good treatment for hyperlipemia (it lowers cholesterol), and this was without affecting proteinuria (the prevention of excretion of amino acids) (12). Generally, steroids affect proteinuria positively, as you'd expect (and want) them to. This stuff is DHT-derived, and it also appears to have a relatively low androgen binding ability, which makes the lack of effect it had on proteinuria when compared with it's anabolic rating even more confusing. It should be noted that doses used in this study were oddly high for a product which comes in 1mg presentation: 1.1 mg/kg/day. That means a 200 lb bodybuilder would be using about 100 mg/day. I think a reasonable anabolic effect would be had with furazabol roughly 50-100mgs/day. This may also be a decent steroid for use in a cycle if one were worried about cholesterol. You'd get an anabolic effect (remember, its anabolic rating is roughly the same as Winstrol's); thus you could build muscle and lower cholesterol with just one pill. Well, actually about a hundred pills, since it comes in 1mg form. Why make a pill in 1mg form if you need to take 100/day? Furazabol is not estrogenic in any way. It's structure and its lack of estrogenic action make it an appropriate precontest drug, as I can't imagine anything gained with it being less than high-quality muscle. There is only a slim chance of androgenic risk, so this may be a nice drug for women as well as men, although certainly not worth consideration for the latter as a stand-alone anabolic. The most unfortunate part about this drug is it's current availability (low) and cost (high). As a quick recap, let's just keep in mind that this stuff is essentially Winstrol that helps your cholesterol instead of harming it. When looking at the steran nucleus of both Winstrol and Miotolan (a likely candidate because, as I said, it also lowers cholesterol). They are both DHT-derived, which I knew off-hand, and this made me more curious about subbing Miotolan for the Winny. Anyway, they are DHT-Derived with a 17-alpha-methyl group (making them methylated, or 17aa, for oral availability). Neither have a 3-keto group; both having instead 2 nitrogen atoms and 2 double bonds—a very weird looking structure—which also makes them both very weak binders to the AR, perfect for stacking with the strong-binding-Tren. The difference between the two is that in lieu of the 2,3-pyrazol group found in the stanozolol structure, furazabol has a 2,3-furazan group (hence the name). References:
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