Femara (Letrozole)

Quick info about Femara (Letrozole)

Letrozole is the chemical name of Novartis' selective third generation aromatese inhibitor (AI). This drug was developed to fight breast cancer by inhibiting aromatization. It has been shown to reduce estrogen levels by 98% or greater. In at least one documented incidence, Letrozole reduced estrogen in the test subject to undetectable levels, and increased LH, FSH and SHBG. If you are a competitive bodybuilder, letrozole is a must have product for contest prep; no other Ancillary compound will produce a dry and tight look like Letro will.

An effective dose of Letrozole is .25-.5mg/day (I use .25mgs/day), but be forewarned, if you go over that amount, it can kill your sex drive. Also worth noting is that there's a rebound effect on your estrogen when you come off letrozol. Maximum inhibition of the aromatize enzyme has been found to happen at doses as low as 100mcg (2)! In non-cellular systems, letrozole is 2-5 times more potent than anastrozole and exemestane in its inhibition of the aromatize enzyme and activity, and in cellular systems it is 10-20x more potent!

It also lasts quite a long time in your body, but takes awhile to get going--letrozole has a whopping 2-4 day (!) half life, and you need to take Letrozole for 60 days to get a steady blood plasma level. Those are impressive numbers, but here's one of the most interesting things about Letrozole: it may reduce/eliminate/reverse existing gynecomastia!